Serum concentrations following oral administration of methotrexate may be slightly lower than those following intravenous injection.
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the concomitant use of methotrexate, in particular, may lead to severe or even fatal liver-damage or hepatotoxicity.
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folic acid is depleted by methotrexate, so it must be replenished through supplementation.
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this is because methotrexate can cause birth defects or death to a fetus.
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agents such as gold myochrysine , methotrexate, azathioprine imuran , and other immunosuppressive agents are very potent drugs and require careful monitoring by experienced physicians.
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