Likewise, in patients being treated with both metoprolol and an alpha-blocking agent such as clonidine , metoprolol should be discontinued several days before stopping the alpha-blocker to avoid marked rebound hypertension.
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antihypertensive effect of alpha-adrenergic blockers such as guanethidine, betanidine, reserpine, alpha-methyldopa or clonidine may be potentiated by beta-blockers including lopressor.
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anxiolytic drugs, beta blockers and clonidine can also be utilized in dealing with facial blushing.
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you will likely need to gradually reduce the dose before stopping clonidine completely.
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