Geriatric patients with cerebrovascular disease and or renal impairment should be observed particularly closely for signs of amantadine toxicity.
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graham and her team showed that amantadine could stop zyprexa-induced weight gain even after people had already had a weight increase on the medication.
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although anticholinergic-type side effects have been noted with symmetrel amantadine hydrochloride when used in patients with drug-induced extrapyramidal reactions, there is a lower incidence of these side effects than that observed with the anticholinergic antiparkinson drugs.
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symmetrel amantadine hydrochloride should be continued daily for at least 10 days following a known exposure.
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a prudent combination of discontinuing the drug and of providing appropriate referrals to exclude important secondary causes such as a superimposed renal failure, cardiac failure, autoimmune or vasculitic livedo, and ruling out deep vein thrombosis must be an important part of continued clinical follow-up for patients on amantadine.
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