Isoniazid for tuberculosis.
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bosentan moderate isoniazid, inh is a potent inhibitor of cyp3a4 isoenzymes in vitro.
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isoniazid, inh; rifampin major substances that are potent inducers of hepatic cytochrome p450 isoenzyme cyp3a4, such as rifampin, may increase the rate of buspirone metabolism.
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rifampin can increase the metabolism of isoniazid, inh into a hepatotoxic metabolite hydrazine .
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in patients with organisms resistant to isoniazid and or rifampin, follow-up evaluations must be individualized.
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