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Clonidine therapy should generally be gradually tapered when discontinuing therapy to avoid rebound effects from occurring.

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generally, those coming off clonidine must be gradually weaned off the substance through a taper.

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discontinuation of concurrent clonidine should be gradual, with carvedilol discontinued first over 1 2 wk with limitation of physical activity; then, after several days, discontinue clonidine.

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some products that may interact with this drug include arbutamine, blood thinners such as warfarin , disulfiram, thyroid supplements, anticholinergic drugs such as benztropine, belladonna alkaloids , certain drugs for high blood pressure drugs that work in the brain such as clonidine, guanabenz, reserpine .

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clonidine hydrochloride is indicated in the treatment of hypertension.

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