Clonidine therapy should generally be gradually tapered when discontinuing therapy to avoid rebound effects from occurring.

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Likewise, in patients being treated with both metoprolol and an alpha-blocking agent such as clonidine , metoprolol should be discontinued several days before stopping the alpha-blocker to avoid marked rebound hypertension.

Us food and drug administration staff, early communication about an ongoing data review for ezetimibe simvastatin marketed as vytorin , ezetimibe marketed as zetia , and simvastatin marketed as zocor .

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