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The first phase i ii study was performed using three different formulations two kinds of suspensions of indinavir base and dry-filled capsules of indinavir.
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Saquinavir rifampin accelerates the metabolism of protease inhibitors, such as amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir through induction of hepatic p450 cytochrome oxidases, resulting in subtherapeutic levels of the protease inhibitors; in addition, protease inhibitors retard the metabolism of rifampin, resulting in increased serum levels of rifampin and the likelihood of increased toxicity; concurrent use of hiv protease inhibitors with rifampin is only recommended under specific circumstances see general dosing information .
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Methadone administration of indinavir 800 mg every 8 hours with methadone 20 mg to 60 mg daily for one week in subjects on methadone maintenance resulted in no change in methadone auc.
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