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M1 inhibits t-cell proliferation by blocking de novo pyrimidine syn- basic pharmacology thesis and inhibiting the tyrosine kinases that are associ- hydroxychloroquine and chloroquine are similar in ac- ated with certain cytokine and growth factor receptors.


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for patients on a stable digoxin regimen and initiating chloroquine, no initial dose adjustment of either drug has been advised; however, serum digoxin concentrations should be monitored and used for digoxin dose titration as clinically necessary.

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